Four Cases of Mucosal Neuroma Syndrome: Multiple Endocrine Neoplasm 2B or Not 2B?1
نویسندگان
چکیده
منابع مشابه
Multiple Endocrine Neoplasia Type 2B: Early Diagnosis by Multiple Mucosal Neuroma and Its DNA Analysis.
Multiple endocrine neoplasia type 2B (MEN 2B) is a rare disease caused by germline mutations in the RET proto-oncogene and is transmitted in an autosomal dominant fashion. It is characterized by medullary thyroid carcinoma, pheochromocytoma and mucosal neuroma developing in the tongue, lip, intestinal tract, palate etc. Among these neoplasias, mucosal neuroma generally develops from early child...
متن کامل[Multiple mucosal neuromas in the larynx as part of a multiple endocrine neoplasia type 2B].
We present the case of a 28-year-old female diagnosed with multiple endocrine neoplasia type 2B (MEN 2B) when she was 17, consisting of medullary thyroid cancer, bilateral pheochromocytoma, lingual neuromas and marfanoid appearance. Bilateral adrenalectomy was performed as a first step, with complete thyroidectomy and bilateral ganglion dissection and resection of lingual neuromas later on. The...
متن کاملMucosal neuroma syndrome--a phenotype for malignancy.
The mucosal neuroma syndrome is characterised by a typical physical appearance, neuromata on tongue and buccal mucosa, and a high risk of developing medullary thyroid carcinoma and phaeochromocytoma. A case is described and the importance of early recognition for prevention of malignancy is stressed.
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Syndrome de la queue de cheval. A propos de 4 cas. Les auteurs rapportent quatre observations cliniques concernat des malades dont les premiers symptomes se manifesterent par des algies longitemps considerees comme "sciatique·s". L' etude neurologique de ces cas demontrait qu'en realite "les algies sciatiques" n'etaient que des signes mono ou pluri-radiculaires en rapport avec un syndrome...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1998
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.83.1.4504